An Investigation of Hepatitis B Virus Genome using Markov Models

The human genome encodes a family of editing enzymes known as APOBEC3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3). Several family members, such as APO-BEC3G, APOBEC3F, and APOBEC3H haplotype II, exhibit activity against viruses such as HIV. These enzymes induce C-to-U mutations in the negative strand of viral genomes, resulting in multiple G-to-A changes, commonly referred to as 'hypermutation.' Mutations catalyzed by these enzymes are sequence context-dependent in the HIV genome; for instance, APOBEC3G preferen-tially mutates G within GG, TGG, and TGGG contexts, while other members mutate G within GA, TGA, and TGAA contexts. However, the same sequence context has not been explored in relation to these enzymes and HBV. In this study, our objective is to identify the mutational footprint of APOBEC3 enzymes in the HBV genome. To achieve this, we employ a multivariable data analytics technique to investigate motif preferences and potential sequence hierarchies of mutation by APOBEC3 enzymes using full genome HBV sequences from a diverse range of naturally infected patients. This approach allows us to distinguish between normal and hypermutated sequences based on the representation of mono- to tetra-nucleotide motifs. Additionally, we aim to identify motifs associated with hypermutation induced by different APOBEC3 enzymes in HBV genomes. Our analyses reveal that either APOBEC3 enzymes are not active against HBV, or the induction of G-to-A mutations by these enzymes is not sequence context-dependent in the HBV genome

Machine Learning Meets Advanced Robotic Manipulation

Automated industries lead to high quality production, lower manufacturing cost and better utilization of human resources. Robotic manipulator arms have major role in the automation process. However, for complex manipulation tasks, hard coding efficient and safe trajectories is challenging and time consuming. Machine learning methods have the potential to learn such controllers based on expert demonstrations. Despite promising advances, better approaches must be developed to improve safety, reliability, and efficiency of ML methods in both training and deployment phases. This survey aims to review cutting edge technologies and recent trends on ML methods applied to real-world manipulation tasks. After reviewing the related background on ML, the rest of the paper is devoted to ML applications in different domains such as industry, healthcare, agriculture, space, military, and search and rescue. The paper is closed with important research directions for future works

A Comprehensive Review on Autonomous Navigation

The field of autonomous mobile robots has undergone dramatic advancements over the past decades. Despite achieving important milestones, several challenges are yet to be addressed. Aggregating the achievements of the robotic community as survey papers is vital to keep the track of current state-of-the-art and the challenges that must be tackled in the future. This paper tries to provide a comprehensive review of autonomous mobile robots covering topics such as sensor types, mobile robot platforms, simulation tools, path planning and following, sensor fusion methods, obstacle avoidance, and SLAM. The urge to present a survey paper is twofold. First, autonomous navigation field evolves fast so writing survey papers regularly is crucial to keep the research community well-aware of the current status of this field. Second, deep learning methods have revolutionized many fields including autonomous navigation. Therefore, it is necessary to give an appropriate treatment of the role of deep learning in autonomous navigation as well which is covered in this paper. Future works and research gaps will also be discussed

An Overview on Artificial Intelligence Techniques for Diagnosis of Schizophrenia Based on Magnetic Resonance Imaging Modalities: Methods, Challenges, and Future Works

Schizophrenia (SZ) is a mental disorder that typically emerges in late adolescence or early adulthood. It reduces the life expectancy of patients by 15 years. Abnormal behavior, perception of emotions, social relationships, and reality perception are among its most significant symptoms. Past studies have revealed the temporal and anterior lobes of hippocampus regions of brain get affected by SZ. Also, increased volume of cerebrospinal fluid (CSF) and decreased volume of white and gray matter can be observed due to this disease. The magnetic resonance imaging (MRI) is the popular neuroimaging technique used to explore structural/functional brain abnormalities in SZ disorder owing to its high spatial resolution. Various artificial intelligence (AI) techniques have been employed with advanced image/signal processing methods to obtain accurate diagnosis of SZ. This paper presents a comprehensive overview of studies conducted on automated diagnosis of SZ using MRI modalities. Main findings, various challenges, and future works in developing the automated SZ detection are described in this paper

Robust adaptive synchronization of a class of uncertain chaotic systems with unknown time-delay

In this paper, a robust adaptive control strategy is proposed to synchronize a class of uncertain chaotic systems with unknown time delays. Using Lyapunov theory and Lipschitz conditions in chaotic systems, the necessary adaptation rules for estimating uncertain parameters and unknown time delays are determined. Based on the proposed adaptation rules, an adaptive controller is recommended for the robust synchronization of the aforementioned uncertain systems that prove the robust stability of the proposed control mechanism utilizing the Lyapunov theorem. Finally, to evaluate the proposed robust and adaptive control mechanism, the synchronization of two Jerk chaotic systems with finite non-linear uncertainty and external disturbances as well as unknown fixed and variable time delays are simulated. The simulation results confirm the ability of the proposed control mechanism in robust synchronization of the uncertain chaotic systems as well as to estimate uncertain and unknown parameters

BERT-Deep CNN: State-of-the-Art for Sentiment Analysis of COVID-19 Tweets

The free flow of information has been accelerated by the rapid development of social media technology. There has been a significant social and psychological impact on the population due to the outbreak of Coronavirus disease (COVID-19). The COVID-19 pandemic is one of the current events being discussed on social media platforms. In order to safeguard societies from this pandemic, studying people's emotions on social media is crucial. As a result of their particular characteristics, sentiment analysis of texts like tweets remains challenging. Sentiment analysis is a powerful text analysis tool. It automatically detects and analyzes opinions and emotions from unstructured data. Texts from a wide range of sources are examined by a sentiment analysis tool, which extracts meaning from them, including emails, surveys, reviews, social media posts, and web articles. To evaluate sentiments, natural language processing (NLP) and machine learning techniques are used, which assign weights to entities, topics, themes, and categories in sentences or phrases. Machine learning tools learn how to detect sentiment without human intervention by examining examples of emotions in text. In a pandemic situation, analyzing social media texts to uncover sentimental trends can be very helpful in gaining a better understanding of society's needs and predicting future trends. We intend to study society's perception of the COVID-19 pandemic through social media using state-of-the-art BERT and Deep CNN models. The superiority of BERT models over other deep models in sentiment analysis is evident and can be concluded from the comparison of the various research studies mentioned in this article.Comment: 20 pages, 5 figure

Explainable Artificial Intelligence for Drug Discovery and Development -- A Comprehensive Survey

The field of drug discovery has experienced a remarkable transformation with the advent of artificial intelligence (AI) and machine learning (ML) technologies. However, as these AI and ML models are becoming more complex, there is a growing need for transparency and interpretability of the models. Explainable Artificial Intelligence (XAI) is a novel approach that addresses this issue and provides a more interpretable understanding of the predictions made by machine learning models. In recent years, there has been an increasing interest in the application of XAI techniques to drug discovery. This review article provides a comprehensive overview of the current state-of-the-art in XAI for drug discovery, including various XAI methods, their application in drug discovery, and the challenges and limitations of XAI techniques in drug discovery. The article also covers the application of XAI in drug discovery, including target identification, compound design, and toxicity prediction. Furthermore, the article suggests potential future research directions for the application of XAI in drug discovery. The aim of this review article is to provide a comprehensive understanding of the current state of XAI in drug discovery and its potential to transform the field.Comment: 13 pages, 3 figure